Reconstructing sibling relationships in wild populations

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Reconstructing sibling relationships in wild populations

Reconstruction of sibling relationships from genetic data is an important component of many biological applications. In particular, the growing application of molecular markers (microsatellites) to study wild populations of plant and animals has created the need for new computational methods of establishing pedigree relationships, such as sibgroups, among individuals in these populations. Most ...

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Reconstructing Sibling Relationships from Microsatellite Data

1 Department of Computer Science, University of Illinois at Chicago, 851 South Morgan Street, Chicago, IL 60607, {tanyabw,ssheikh,[email protected]} 2 Department of Industrial Engineering, Rutgers University, PO Box 909, Piscataway, NJ 08855, [email protected], 3 Department of Biological Sciences, University of Illinois at Chicago, 840 West Taylor Street, Chicago, IL 60607, ashley@eeb....

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Combinatorial Reconstruction of Sibling Relationships

We present a new algorithm for reconstructing sibling relationships in a single generation of individuals without parental information, using data from codominant DNA markers such as microsatellites. We use the simple genetic constraints on the full-sibling groups, imposed by the Mendelian inheritance rules, and combinatorial optimization techniques to extract a minimum number of consistent sib...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2007

ISSN: 1460-2059,1367-4803

DOI: 10.1093/bioinformatics/btm219